Journal of AdvancedMedical and Dental Sciences Research

Background: Tuberculous involvement of liver as a part of disseminated tuberculosis is seen in up to 50-80% cases. Indirect involvement of liver in the form of amyloidosis, fatty liver or drug toxicity in tuberculosis (TB) is common. The present study was conducted to asses various cases of HBTB. Materials & Methods: It is a retrospective study which included 320 cases of tuberculosis. The presence of hepatobiliary involvement was suspected on the basis of abnormal liver function tests (LFT) and/or imaging findings. In all patients detailed clinical history and clinical examination was done. Liver function tests, viral markers, USG, CT, MRI and histopathology/microbiology & culture for mycobacteria were done as and when required. Results: Out of 320 TB patients, 252 did not show any hepatobiliary involvement and only 68 showed hepatobiliary involvement. 40 had hepatobiliary TB (HBTB) and 28 had not. Those who had HBTB, 20 were of biliary TB, 15 were of hepatic TB and 5 were of mixed HBTB. The difference was non significant (P>0.05). Commonly seen symptoms were fever, weight loss, jaundice, hepatomegaly and splenomegaly. Bilirubin, ALT, AST, ALP were raised in hepatic, biliary and HBTB cases. Conclusion: Hepatobiliary tuberculosis is not uncommon form of tuberculosis. Clinical features and laboratory findings are useful in diagnosis of the disease.
Key words: Hepatobiliary tuberculosis, hepatomegaly, splenomegaly.

Corresponding author: Dr. Namrata Punit Awasthi, Associate Professor, Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, U.P., India

This article may be cited as: Singh P, Awasthi NP. Clinical and Laboratory Findings in Patient’s with Hepatobiliary Tuberculosis. J Adv Med Dent Scie Res 2017;5(12):1-3.