Journal of AdvancedMedical and Dental Sciences Research

Background: Chronic urticria has a wide range of clinical presentations and etiologies. Such cases have associated autoimmune diseases, high wheal and itch score and presence of associated systemic symptoms. Managing cases of autoimmune urticaria still remains a dilemma. Immunosuppresive drugs are useful in some cases but their use is limited because of side effects and prolonged therapy. The present study was conducted with the aim to determine the clinic epidemiological features of patients with positive and negative ASST. Materials and methods: The present prospective study was conducted in the Department of Dermatolgy, Venereology& Leprology Moti Lal Medical College Allahabad (U.P.) Institute. The study was conducted over a period of one year i.e. from may 2014 to June 2015. All the cases of chronic urticaria irrespective of caste, gender aged between 18-60 years were included in the study. Complete history including all the demographic detail was obtained from all the patients. Thorough clinical examination was done along with complete blood and urine evaluation. ASST was performed in all the patients after weaning them from antihistaminics, steroids or immunosuppresants. The details of the patients were arranged in a tabulated form and analysed using SPSS software. Two tailed t test was used for statistical analysis. Probability value of less than 0.05 was considered significant. Results: There were 22 males and 18 females in ASST positive group. In ASST negative group, there were 28 males and 12 females. The mean duration of disease was 22.45 +/- 9.53 and 16.33 +/- 9.79 in ASST positive and negative group respectively. Out of 110 subjects, 45 were ASST positive and 65 were ASST negative. In 18-27 year age group, there were 31.1% (n=14) subjects who belonged to ASST positive group and 26.2% (n=17) subjects who belonged to ASST negative group. One patient in ASST positive group had headache. 4 patients in ASST positive and 3 patients in ASST negative group had arthralgia. Conclusion: From the above study we can conclude that there was no significant difference in the clinicoepidemiological parameters of autoimmune urticaria and chronic urticaria.
Keywords: Autoimmune, Epidemiological, Prospective, Urticaria.

Corresponding author:  Dr. Sudha Yadav, Associate Professor, Department of Skin, V D & Leprosy, MLN Medical College, Allahabad, U.P., India

This article may be cited as: Yadav S, Jain D. Clinico Epidemiological Study of Autoimmune Urticaria in a Tertiary Care Center. J Adv Med Dent Scie Res 2017;5(10):7-10.