Journal of AdvancedMedical and Dental Sciences Research

Background: Methotrexate (MTX) remains the foundation treatment for patients with rheumatoid arthritis (RA), with entrenched wellbeing and viability profiles and support in universal rules. Clinical and radiologic comes about show advantages of MTX monotherapy and blend with different specialists, yet patients may not get ideal dosing, span, or course of organization to augment their reaction to this medication. The primary goal of this investigation is to evaluate efficacy and safety of methotrexate either alone or in combination with hydroxychloroquine in patients with Rheumatoid arthritis. Materials and Methods: Patients with dynamic rheumatoid arthritis taking MTX for >3 months were incorporated into this investigation and were partitioned in two gatherings, Group-1 (n=30) patients got methotrexate (MTX) and Group-2 (n=30) patients got Methotrexate + Hydroxychloroquine (HCQ) twice every day. The patients were followed up for a time of 4 months. Result: The mean time of patients was 42.5 ± 5.6 years. 42 patients were females and 18 were males. 18 patients had positive family history of the ailment. The Rheumatoid factor was certain in 36 and anti-CCP was increased in a large portion of the patients. After 3 months, improvement noted in patients treated mix of methotrexate and hydroxychloroquine. Conclusion: The combination treatment was observed to be more effectual than MTX monotherapy in improving symptoms and personal satisfaction.

Keywords: Rheumatoid Arthritis(RA); Antirheumatic agents; Biological products, Methotrexate (MTX) Hydroxychloroquine (HCQ).

Corresponding author: Dr. Awadhesh Kumar Jha, Associate Professor, Department of Pharmacology, Government Medical College, Betiah, Bihar, India

This article may be cited as: Barkat S, Jha AK. Comparative evaluation of efficacy and safety of methotrexate either alone or in combination with hydroxychloroquine in patients suffering from rheumatoid arthritis. J Adv Med Dent Scie Res 2017;5(8):52-55.