Journal of AdvancedMedical and Dental Sciences Research

The aim of this review is to highlight the occurrence of osteonecrosis of the jaws in patients treated with long term bisphosphonates therapy, also known as Bisphosphonates Related Osteonecrosis of Jaws (BRONJ) and reviews the guidelines for diagnosis, staging and management of the disease. BRONJ is mainly associated with infection, trauma to the jaw bones (such as dental extraction or simple dentoalveolar surgery) in patients with history of bisphosphonates therapy, which leads to failure of bone healing and ultimately bone necrosis, but it can also occur on its own. Bisphosphonates affect calcification by physicochemical mechanism. it also affects bone resorption at three levels mainly cellular, tissue and molecular level. Treatment of BRONJ depends on the stage of the disease, dose and type (IV or oral) of bisphosphonates intake. However, conservative approach is best method for treating BRONJ.
Keywords: Osteonecrosis, Jaws, Bisphosphonate (BPs).

Corresponding author: Ritika, BDS, Sri Guru Ram Das Institute of Dental sciences & Research, Amritsar, Punjab.

This article may be cited as: Ritika,  Gill SK, Sandhu  GK. Bisphosphonate related osteonecrosis of jaw: A review. J Adv Med Dent Scie Res 2017;5(5):16-20.