Journal of AdvancedMedical and Dental Sciences Research

Background:Acne vulgaris, commonly referred to as acne, is a skin condition that occurs when hair follicles become clogged with oil and dead skin cells.The present study was conducted to assess effect of Nadifloxacin and Adapalene in the treatment of acne vulgaris. Materials & Methods:76 cases of acne vulgarisof both genderswere prescribed 1% nadifloxacin and 0.1% adapalene gel for 8 weeks. The major efficacy variables measured at 2 weeks, 4 weeks, and 8 weeks were reductions in the overall, inflammatory, and non-inflammatory lesion counts from the baseline. Results: Out of 76 patients, males were 46 and females were 30. The mean severity score for inflammatory lesions at baseline was 19.2, at 2 weeks was 13.4, at 4 weeks was 10.1 and at 8 weeks was 7.8 and for non- inflammatory lesions was 58.4, 40.6, 32.4, and 19.2 respectively. The difference was significant (P< 0.05). At baseline, 2 weeks, 4 weeks and 8 weeks, mild lesions were8, 12, 14 and 37 respectively. There was reduction in severe lesions from 48 to 35, 28 and 6 from baseline, 2 weeks, 4 weeks and 8 weeks. The difference was significant (P< 0.05). Conclusion: For the treatment of mild to severe acne vulgaris, a fixed combination of 1% nadifloxacin and 0.1% adapalene topical gel may be a useful and well-tolerated choice.