Journal of AdvancedMedical and Dental Sciences Research

Aim: Comparative study on the use of Etomidate and Propofol for inducing general anesthesia. Material and methods: This clinical study was conducted on 100 patients aged between 18 to 65 years undergoing Elective surgeries under general anaesthesia. After institutional ethical committee approval, 100 patients belonging to ASA grade 1 or 2 aged between 18 to 65 years, undergoing elective surgeries under general anaesthesia were randomly selected. All patients were visited and evaluated thoroughly on the previous day of surgery. Group E: Comprised of 50 patients induced with injection, Etomidate 0.3mg/kg iv for induction of general anaesthesia. Group P: Comprised of 50 patients induced with injection, Propofol 2mg/kg iv for induction of general anaesthesia. Results: Mean induction time in Group E and Group P were 22.44±2.33seconds and 27.65±2.34 seconds respectively. Time for induction in Etomidate was significantly shorter compared to Propofol group (p value <0.05). There is increase in Heart rate after intubation in Propofol group 98.20±10.05 at 1 min, 97.05±10.12 at 2 min and 95.50±9.89 at 3 min compared to Etomidate group. This was statistically significant (p value≤0.001). Compared to Propofol group, pain on injection is less in Etomidate group. Pain Score among two groups is statistically significant (p value < 0.001). Conclusion: Etomidate is a superior inducing drug for general anesthesia compared to Propofol due to its hemodynamic stability, lower incidence of pain upon injection, and shorter induction time.