Journal of AdvancedMedical and Dental Sciences Research

Background:Genetics, neurobiology, clinical course, treatment plans, and prognosis distinguish bipolar (BP) from unipolar (UP) disorders. The present study compared the clinical profile of patients with unipolar and bipolar depression. Materials & Methods:80 patients of unipolar and bipolar depression of both genders were classified in groups I and II, respectively. Bipolar and unipolar patients' clinical profiles and sociodemographic information were documented. Results: Out of 80 patients, males were 48 and females were 32. The total duration was 12.5years and 16.4 years, the age of onset was 30.4years and 20.5, number of episodes was 3.1 and 7.2, panic symptomswere seen in 12 and 8, delusions in 14 and 2, anhedonia in 18 and 14, pseudodementia in 6 and 2, suicidal thoughts in 3 and 6, catatonic features in 9 and 5 and depressive cognitions in 4 and 5. The difference was significant (P< 0.05). Conclusion: The authors found that the QOL profiles of patients with bipolar and unipolar depression differ. It is now even more crucial to rule out bipolarity in patients with first-episode depression in light of the BP spectrum idea. Sufficient steps have to be takento comprehend the clinical indicators of bipolar disorder.