Journal of AdvancedMedical and Dental Sciences Research

Aim: Prospective research analyzing hematological parameters in cases of newborn sepsis. Materials and methods: A total of 100 neonates were included in this study. The study included all neonates with features of sepsis and thoseneonates having predisposing factors or history suggestive of sepsis. Results: A total of 100 neonates were classified into three categories, sepsis(n=39), probable infection (n=25), and normal (n=36), based on the clinical examination and laboratory findings. The total number of culture positive cases was 42 (42%) and culture was bacteriologically negative in 58(58%) cases. The total number of preterm babies was 56 (56%) while 44(44%) were term babies. Preterm babies were more affected by sepsis than term babies. There were 59 (59%) males and 41(41%) females. 3 (8.33%) of the normal neonates had score ≥5 suggesting the presence of sepsis, 6(16.67%) had scores 3-4 suggesting possibility of sepsis, and 27(75%) normal cases had scores ≤2 which suggested less likely sepsis in these cases. The sensitivity of CRP test was 68% and specificity was 79%. PPV of the CRP test was 69%. White blood cells (WBCs) count had sensitivity of 61% and specificity of 91%. PPV was 83%. This result was statistically significant. Platelet count showed sensitivity of 82%, PPV was 72% and p<0.0001. Cells with degenerative changes showed sensitivity of 71% and specificity of 63%. PPV of the test was 52% and p=0.002. Conclusion: Detecting newborn septicemia may be challenging due to the inconspicuous and varying early symptoms of sepsis at various stages of gestation. The HSS is an uncomplicated, expeditious, and economical instrument that may be used as a screening test for promptly detecting newborn sepsis.