Journal of AdvancedMedical and Dental Sciences Research

INDUCIBLE CLINDAMYCIN RESISTANCE IN CLINICAL ISOLATES OF STAPHYLOCOCCUS AUREUS IN A TEACHING HOSPITAL

Clindamycin is widely used for treatment of skin and soft tissue infections caused by staphylococci. However inducible clindamycin resistance may be missed in routine in vitro susceptibility test for clindamycin. The present study was conducted to determine the prevalence of inducible clindamycin resistance in Staphylococcus aureus isolates from various clinical specimens. Isolates were subjected to antimicrobial susceptibility testing for erythromycin, clindamycin and  cefoxitin. Inducible clindamycin resistance was tested by D test.
D test was found to be positive in 21.57% of the isolates. Inducible clindamycin resistance was found to be1 more in methicillin resistant isolates as compared to methicillin sensitive isolates. D test should be used as a routine method for detection of inducible clindamycin resistance, thus avoiding therapeutic failures.
Keywords: Erythromycin , Clindamycin , Staphylococcus aureus, D test, Methicillin