Journal of AdvancedMedical and Dental Sciences Research

Background: This study aims to assess the effectiveness of Letrozole and Clomiphene Citrate (CC) as two commonly used medications for promoting ovulation. The research focuses on women undergoing Intrauterine Insemination (IUI) and aims to compare the impact of Letrozole and CC on several key factors, including the total number of follicles, endometrial thickness, hormone levels, and pregnancy rates. Methods: In our research, we enrolled 126 participants over the course of one year.The study consisted of two groups, with 70 patients in the Letrozole group and 56 patients in the CC group. Both groups underwent serial Transvaginal Ultrasound (TVS) examinations until a mature follicle with a diameter of 18 mm was observed. Gonadotropin injections were administered as needed in each cycle, followed by an hCG trigger injection. Subsequently, Intrauterine Insemination (IUI) was performed 34-36 hours after the hCGtrigger. Results: In our study, we observed that the endometrial thickness was significantly greater in the CC group compared to the Letrozole group, a finding that correlated with another significant outcome in our research: the CC group exhibited higher pregnancy rates than the Letrozole group. Additionally, our study revealed that the Letrozole group had a greater number of follicles compared to the CC group. Interestingly, the mean dose of Gonadotropin required was lower in the Letrozole group compared to the CC group. Conclusion: Clomiphene Citrate (CC) has traditionally been the preferred choice for ovulation induction for many years. However, our study yielded interesting findings. We observed that patients who received CC had a statistically greater endometrial thickness compared to those on Letrozole, and the CC group demonstrated higher pregnancy rates. On the other hand, the Letrozole group exhibited a higher number of dominant follicles and required fewer units of additional Gonadotropins.Based on these results, it appears that Letrozole could be a promising option for ovulation induction, with the potential for more efficient follicular development and reduced need for supplementary Gonadotropins.