Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was conducted for evaluating gallbladder mucosal changes among patients with gallstones. Materials & methods: 100 gallstone patients who were scheduled to undergo Cholecystectomy were enrolled. Only those patients were enrolled which had symptomatic cholecystitis due to cholelithiasis irrespective of age or gender. The tissue was properly sampled and processed by routine histological techniques for paraffin embedding and sectioning at 4 micron thickness. Four sections including entire wall were obtained: two from body, one each from fundus and neck of the gall bladder. Additional sections were taken from abnormal mucosa. Histopathological diagnosis was established on routine hematoxylin and eosin staining of the sections. Results: Adenomatous hyperplasia, Chronic cholecystitis, Hyperplastic polyp with chronic cholecystitis and Malignancy was present in 32 percent, 33 percent, 22 percent and 13 percent of the patients respectively. Non-significant results were obtained while correlating Gallbladder mucosal changes and number of stones in gallbladder (p-value > 0.05). Conclusion: Gallstones are accompanied by major changes in the gallbladder epithelium which might be due to irritation to the mucosa by stones.