Journal of AdvancedMedical and Dental Sciences Research

Aim: Investigation of HbA1c as a potential biomarker for assessing dyslipidemia and atherogenicity in individuals with type 2 diabetes mellitus. Methods: This study conducted in the department of medicine. Total 140 diagnosed cases of DM type 2 in the age group of 20-70 years were include in this study. The patients were divided into 2 groups depending on the levels of glycated hemoglobin. Venous blood samples from all the subjects were collected after at least 6 hours fasting and analyzed for fasting plasma glucose (FPG), 2 hours post prandial glucose levels(2hPG), serum total cholesterol(TC), triglycerides(TG),HDL-C, Very low density lipoprotein cholesterol(VLDL-C) & LDL-C analysis was done by standard methods. The atherogenic index of plasma (AIP) was calculated by the formula base 10 logarithm of the ratio of TG to HDL-C. Results: Out of the 140 patients studied, there were 60 males and 80 females. The maximum number of patients was in the age group of 50-60 years. The levels of FBG, TC, TG,VLDL-C LDL-C, HbA1c, AIP, ratios of TC/HDL-C and LDL-C/HDL-C are increased, while the levels of HDL-C are decreased in patients with HbA1c >7% as compared to patients with HbA1c ≤ 7% and these values are highly significant. The patients with HbA1c >7% had dyslipidemia as the most prominent feature in the lipid profile. Direct and significant correlation of HbA1c with FBG, 2Hpg were found. It also shows direct and highly significant correlation of HbA1c with TC, TG, LDL-C, TC/HDL-C, LDL-C/HDL-C and AIP, and inverse correlation between HbA1c and HDL. the patients with HbA1c >7% were more prone to cardiovascular risk as their levels of AIP fall in the high risk group i.e AIP > 0.22 and the association was highly significant proving that glycemic control contributes significantly to the future risk of cardiovascular problems. The lipid parameters of patients with HbA1c <7% were in the normal range but the AIP levels still fell in the risk group. Conclusion: The findings of this research suggest that individuals with inadequate glycemic control have an atherogenic lipid profile, and it is possible to predict dyslipidemia and atherogenicity using the measurement of Glycated haemoglobin.