Journal of AdvancedMedical and Dental Sciences Research

Background: Lower urinary tract symptoms (LUTS) in perimenopausal female are mainly due to urethral stenosis. The present study was conducted to compare alpha-1a blockers (tamsulosin) versus estrogens in the treatment of lower urinary tract symptoms in perimenopausal females. Materials & Methods: 74 perimenopausal females between the age group of 45 and 60 years who present with the symptom of voiding LUTSwere divided into two groups. Group I was given alpha blocker (tamsulosin) and group II was given topical estrogen application (0.5%–1%) in the periurethral region. Patients were followed up clinically by voiding components of the international prostate symptom score and objectively by uroflowmetry and postvoid residual (PVR) urine estimation (ultrasonography). Results: Pre- treatment Qmax in group I was 7.4 and in group II was 7.1 and post- treatment Qmax in group I was 18.2 and in group II was 10.5. The difference was significant (P< 0.05). Pre- treatment PVR in group I was 120.5 ml and in group II was 124.6 ml and post- treatment PVR in group I was 36.8 ml and in group II was 110.4 ml. The difference was significant (P< 0.05). Conclusion: Alpha-1a blockers should be used as the first-line medical management in perimenopausal females with symptoms of LUTS, as they have a clear advantage over topical estrogens.