Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was conducted for comparing the efficacy and safety of microneedling followed by methotrexate 1% gel versus microneedling followed by tacrolimus solution (0.1%) in localised stable vitiligo. Materials & methods: 20 patients with localized stable vitiligo were enrolled after meeting the inclusion and exclusion criteria. They were randomly divided into 2 groups of 20 patients each. A 1% gel of methotrexate was administered to Group 1; a 0.1% ointment of tacrolimus was applied to Group 2. Both groups had their dressings changed after 24 hours. Then, it was suggested to the patients to apply the drug twice daily. Up to 24 weeks, this operation was done every three weeks. In Groups 1 and 2, Microneedling was carried out using tacrolimus solution and methotrexate gel, respectively, and was followed with dressings. For a maximum of six months, the operation was repeated every three weeks. Patients were subsequently instructed to apply the medication twice each day. Each patient's therapy success was assessed objectively by the Vitiligo Area Severity Index (VASI). Results: The mean age in Group 1 was 35.5 years and in Group 2 34.2 years respectively. 60 percent of the patients of group 1 and 70 percent of the patients of group 2 were females while the remaining were males. As assessed by VASI Score, significant better results were obtained among patients of group A. Conclusion: Microneedling followed by methotrexate 1% gel in comparison to microneedling followed by tacrolimus solution (0.1%) in localised stable vitiligo showed significantly better improvement.