Journal of AdvancedMedical and Dental Sciences Research

Background: Electro convulsive therapy is used to treat depression in the patients not responding to antidepressant therapy. The present study compared efficacy of Ketofol and Propofol for electroconvulsive therapy in motor seizure. Materials & Methods: 50 patients with motor seizurewere divided into two groups of 25each. Group I was given initial dose of 0.5mg/kg Propofol. Group II was administered an initial dose of 0.5mg/kg Ketofol (0.25 mg/kg of Propofol + 0.25 mg/kg of ketamine). Parameters such as motor seizure duration, hemodynamicprofile and recovery times were recorded. Results: Group I had 14 males and 11 females and group II had 2 males and 13 females. Motor seizure duration was 21.5seconds in group I and 27.4seconds, time of spontaneous eye-opening was 580.8seconds and 548.6 seconds, time of obeying commands was 728.3seconds and 738.4 and time of spontaneous breathing was 340.1 and 312.6 in group I and II respectively. The difference was non- significant (P> 0.05). There was non- significant difference in group I and group II regarding heart rate (bpm), systolic BP (mmHg), diastolic BP (mmHg), MAP (mmHg) and SPO2 (%) 1 minute and 5 minutes after seizure (P>0.05). Conclusion: Both Ketofol and Propofol produced adequate motor seizure duration. Both agents can be comparable in terms of recovery parameters.