Journal of AdvancedMedical and Dental Sciences Research

Background: Trigeminal neuralgia (TN) is the most common among the neuralgias. The present study compared carbamazepine and combination of carbamazepine with baclofen in the management of trigeminal neuralgia. Materials & Methods: 50 patients of trigeminal neuralgia of both genderswere divided into 2 groups. Group I patients received 600–800 mg/day carbamazepine twice daily and group II received 600 mg/day carbamazepine plus baclofen 10–20 mg/day twice daily. Patients were recalled after 7 days, 15 days and 30 days. Results: Group I had 12 males and 13 females and group II had 11 males and 14 females. The mean pain (VAS) at baseline was 9.2 in group I and 9.0 in group II, at 7 days was 6.7 in group I and 5.2 in group II, at 15 days was 5.6 in group and 3.1 in group II and at 1 month was 4.5 in group I and 1.6 in group II. The difference was significant (P< 0.05). Conclusion: Carbamazepine in combination with baclofen is more effective as compared to Carbamazepine alone in reducing pain in patients with trigeminal neuralgia.