Journal of AdvancedMedical and Dental Sciences Research

Background: The key to success of orthodontic treatment needs periodontal health, oral hygiene, and optimal orthodontic forces. The present study was conducted to assess IL- IB and IL- 8 level in patients undergoing orthodontic treatment. Materials & Methods: 30 patients requiring orthodontic treatment of both genderswere divided into 2 groups of. Each group comprised of 15 patients. Group I was vibrational and fixed appliance group and group II was fixed appliance group only. Collection of unstimulated whole saliva in a sterile test tube was done and the targeted biomarkers such as IL1band IL18 were analyzed using ELISA assay test. Results: Group I had 6 males and 9 females and group II had 7 males and 8 females. Irregularity index at time point T0 was 8.5 in group I and 9.7 in group II, at T1 was 5.4 in group I and 5.9 in group II, at T2 was 2.5 in group I and 2.7 in group II and at T3 was 1.2 in group I and 1.0 in group II. The difference was significant (P< 0.05). The mean IL- IB level at T0 was 42.5 and 81.5, at T1 was 27.3 and 56.4, at T2 was 30.7 and 105.3 and at T3 was 27.8 and 130.5. The difference was significant (P< 0.05). The mean IL- 8 level at T0 was 260.4 and 245.5, at T1 was 185.7 and 173.2, at T2 was 193.2 and 256.5 and at T3was 291.4 and 380.2 in group I and II respectively. Conclusion: There was no difference in the expression of IL- IB and IL- 8 between both groups.