Journal of AdvancedMedical and Dental Sciences Research

Aim: The study's goal is to determine the frequency of liver function abnormalities in heart failure patients, the pattern of elevation of liver enzymes, and the connection of liver function tests with the aetiology, duration, and severity of heart failure. Material and methods: This is a prospective study was conducted in the Department Biochemistry. The hepatic biochemical parameters like serum bilirubin (direct, indirect and total), serum AST and ALT, Serum alkaline phosphatase, Serum proteins and Prothrombin time were estimated. Results: Regarding hepatic biochemical parameters there is significant variation in serum bilirubin (mg/dl) parameter as per progress in class of heart failure (p=0.001). Serum bilirubin was 3.88±1.57 mg/dl in class IV and least in class I that is 1.132±0.28 mg/dl. Serum AST was highest in class IV 161.14±25.85 IU and least in class I that is 35.68±11.87 IU (p=0.001). Serum ALT was highest in class IV 188.98±35.85 IU and least in class I that is 35.11±10.56 (p=0.001). Serum ALP was highest in class IV 62.27±15.32 IU and least in class I that is 39.48±8.85 (p=0.01). Serum total protein (g/dl) was decreased as the heart failure progressed least in class IV 3.59±1.47 g/dl and highest in class I that is 6.78.14±2.14 gm/dl (p=0.05). Serum albumin (g/dl) was least in class IV 2.79±0.82 g/dl and highest in class I that is 4.75±0.85 gm/dl (p=0.034). Prothrombin time (sec) was highest in class IV 23.24±6.11 sec and least in class I that is 13.12±3.36 sec (p=0.01). it is clear that serum bilirubin was increased with the duration of disease. The mean value of serum bilirubin (mg/dl) in patients with duration of disease more than 4 year was 3.11±1.17 mg/dl was significantly higher than the patients with duration of disease less than 4 year significantly (p=0.02). Serum AST was highest with duration of disease more than 4 year 112±26.34 IU and least in patients with duration of disease less than 4 year that is 40.57±8.94 IU (p=0.001). Serum ALT was highest with duration of disease more than 4 year 159.87±26.38 IU and least in patients with duration of disease less than 4 year that is 34.12±8.94 IU (p=0.001). Serum ALP IU was highest with duration of disease more than 4 year 60.12±10.14 IU and least in patients with duration of disease less than 4 year that is 40.15±4.57 IU (p=0.02). Serum total protein (g/dl) was least with duration of disease more than 4 year 4.12±2.22 g/dl and normal in patients with duration of disease less than 4 year that is 6.77±1.58 g/dl (p=0.029). Serum albumin (g/dl) was least with duration of disease more than 4 year 2.77±1.44 g/dl and normal in patients with duration of disease less than 4 year that is 3.84±0.79 g/dl (p=0.14). Conclusion: In conclusion, we found that heart failure was most prevalent in men's sixth and seventh decades. Ascites and jaundice were also prevalent, as was a swollen liver. The severity and duration of cardiac disease were both shown to be predictive of the degree of change in biochemical markers.