Journal of AdvancedMedical and Dental Sciences Research

Background: Preoperative preparation of a child undergoing surgery is a major challenge to the anesthesiologists. The present study compared the efficacy of midazolam with clonidine in children. Materials & methods: 80 patients with ASA grade I and II of both genders were divided into 2 groups of 40 each. Group I received 4 mcg/kg of oral clonidine and group II received 0.5 mg/kg oral midazolam as a premedication about 1hour before induction of anaesthesia. Drug acceptance and anxiety score was recorded. Drug acceptance was calculated. Results: The mean pulse rate was 87.4 in group I and 86.2 in group II. SBP was 100.2 mm Hg in group I and 104.6 mm Hg in group II, DBP was 68.4 mm Hg in group I and 65.2 mm Hg in group II. Respiratory rate was 20.5 cycles/ minute in group I and 20.8 cycles/ minute in group II. Duration of surgery was 134.2 minutes in group I and 136.4 minute in group II. The difference was non- significant (P> 0.05). Drug acceptance score 1 was seen in 24 in group I and 14 in group II, 2 in 10 in group I and 18 in group II. Score 3 was seen in 6 in group I and 8 inn group II. The difference was significant (P< 0.05). The mean sedation score in group I was 2.9 and in group II was 1.1. The difference was significant (P< 0.05). Conclusion: Authors found that clonidine offered better sedation and drug acceptance score in children and hence could be used as an alternative to midazolam as pre- anesthetic agent.