Journal of AdvancedMedical and Dental Sciences Research

Background: To assess proportion of rifampicin and isoniazid resistance in sputum positive smear cases of pulmonary tuberculosis. Materials & method: A total of 100 patients with potential symptoms suggestive of pulmonary tuberculosis and history of treatment with antituberculosis drugs reported to Chest and T.B department. All sputum smears positive cases with previous history of treatment with first line antituberculosis drugs were instructed to collect sputum sample in a sterile, leak proof falcon tube. The samples were immediately sent to Intermediate Reference Laboratory, Patiala for Line Probe Assay, as per guidelines. All the data were compiled in Microsoft excel sheet and were analysed by SPSS software. Results: H (Isoniazid): Sensitive, R (Rifampicin): Sensitive was found to be present in 59 percent of the patients, while R: Sensitive, H: Resistant was found to be present in 21 percent of the patients. H: Sensitive, R: Resistant was found to be present in 11 percent of the patients while H: Sensitive, R: Sensitive was found to be present in 9 percent of the patients. Conclusion: Since drug-resistance is a dynamic phenomenon, it is important to monitor the trend of drug-resistance periodically.