Journal of AdvancedMedical and Dental Sciences Research

Background: Electroconvulsive therapy is a common treatment method used in severe depression and other psychiatric diseases. The present study compared efficacy of Ketofol and Propofol for electroconvulsive therapy in motor seizure. Materials & Methods: 60 patients with motor seizurewere divided into two groups of 30 each. Group I was given initial dose of 0.5mg/kg Propofol. Group II was administered an initial dose of 0.5mg/kg Ketofol (0.25 mg/kg of Propofol + 0.25 mg/kg of ketamine). Parameters such as motor seizure duration, hemodynamicprofile and recovery times were recorded. Results: Motor seizure duration (sec) was 25.5 and 28.4, time of spontaneous eye-opening (sec) was 592.8 and 544.8 and time of obeying commands (sec) was 720.3 and 734.2 and time of spontaneous breathing (sec) was 342.1 and 307.2 in group I and II respectively. The difference was significant (P< 0.05). There was non- significant difference in Group P and group K regarding heart rate (bpm), systolic BP (mmHg), diastolic BP (mmHg), MAP (mmHg) and SPO2 (%) 1 minute and 5 minutes after seizure (P>0.05). Conclusion: Both Ketofol and Propofol produced adequate motor seizure duration. Both agents can be comparable in terms of recovery parameters.