Aim: to assess the alteration serum creatine phosphokinase level in different grades of oral squamous cell carcinoma.
Methods: twenty three patients with histopathologically diagnosed cases of oral squamous cell carcinoma and 23 age & sex matched healthy individuals ((group I), were randomly selected in present study. Incisional biopsy was performed from the clinically most representative areas and fixed in 10% natural buffer formalin, process and cut by rotary microtome to obtain paraffin sections of 5 microns. Each section was stained using Hematoxylin and Eosin stain. 2ml antecubital venous blood samples were collected from all subjects after fasting overnight and centrifuged for 5 min to obtain serum sample. Results: Serum CPK level when compared Between Group I(control) and Group II shows not significant result. When compared between Group I(control) and Group III and between Group I(control) and Group IV, it shows significant results. Conclusion: There are definite underlying biochemical changes in serum of patients with oral Squamous cell carcinoma. As well as potential relation between elevated serum CPK level and oral cancer can be a useful biochemical marker for assessing such life threatening malignant lesion
Key words: Oral cancer, Oral squamous cell carcinoma, Patients, Serum creatine phosphokinase
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