Journal of AdvancedMedical and Dental Sciences Research

Background: Tuberculosis is one of the commonest chronic infectious diseases; highly endemic in India kills five lakh patients every year. Oxidative Stress plays important role in inflammatory & degenerative diseases including pulmonary tuberculosis. There is hardly any one study available in literature correlating oxidative stress, lipid profile values and antioxidant status together with the pulmonary tuberculosis; so we decided to conduct this study. Methods: Study group included newly diagnosed 50 cases of pulmonary tuberculosis and control group included 50, age and sex matched healthy volunteers and employees. All the subjects were subjected to complete physical and systemic examinations, routine investigations including Sputum for AFB by Ziehl-Neelsen staining, AFB culture and Chest x-ray and special tests like Erythrocyte sedimentation rate (ESR), Malondialdehyde (MDA) and Adenosine deaminase (ADA) and findings recorded and statistically analysed. Results: In the study group with 33 males and 17 females, we found Serum MDA mean ± SD 2.91±0.99; Serum ADA 38.15±13.47 while The mean levels of pleural fluid MDA and ADA in tubercular patients were found to be 1.65+0.53 n mole/ml and 56.88+22.1 U/L respectively. While in controls with 61 males and 39 females, these values were 1.72±0.45 n mole/ml (MDA), 20.15± 6.70 U/L (ADA) respectively. Conclusion: Tuberculosis effect more males (66%) than females (34%). Malondialdehyde (MDA) and Adenosine deaminase (ADA) were found statistically significantly higher in study group when compared with control, (p <0.001). Antioxidant plays important role for prevention of pulmonary Tuberculosis.