Journal of AdvancedMedical and Dental Sciences Research

Aim: To determine the prognostic value of some serum protein fractions as Early Index of Clinical Recovery in Pulmonary Tuberculosis patients. Methods: The Department of Pulmonary Medicine conducted this cross-sectional investigation. For this study, 80 people between the ages of 20 and 50 were readily recruited. There were 40 clinically diagnosed PTB patients who did not have HIV or malaria co-infections. They were further subdivided into drug-naive TB subjects 20 and TB subjects on ATT 20. The remaining 40 were age-matched apparently healthy controls (40 girls and 20 men). Results: The results indicated that BMI (kg/m2) was considerably reduced in drug naive TB participants (20.25± 2.75), and in TB subjects on ATT (21.30± 2.80) as compared to control subjects (25.58± 3.05) (p ¼0.000). The difference in mean weight (kg) between TB participants on ATT (59.17± 4.62) and treatment naïve TB subjects (52.47± 10.50) was not statistically significant (p ¼ 0.10). The mean blood total protein levels (g/dl) in TB participants on ATT (8.82 ±1.64) and treatment naïve TB subjects (9.02± 1.77) were substantially greater as compared to the control subjects (7.78 0.89) (p > 0.002). The mean (SD) serum albumin (g/dl) in TB participants on ATT was substantially greater (5.41± 1.47) as compared to control subjects (3.73± 1.05) (p ¼ 0.000). When compared to the control (3.73± 1.05), the medication naïve TB participants had substantially reduced mean serum al- bumin (2.78± 0.77) (p ¼ 0.000). The mean serum globulin (g/dl) level in TB participants on ATT (3.41± 1.52) was considerably lower than in their non-ATT counterparts (6.23± 1.86) (p ¼0.000). However, as compared to control participants, both groups of TB subjects had substantially higher mean blood globulin levels (3.85 ±1.40) (p ¼ 0.000). Similarly, the mean level of albumin- globulin ratio was significantly higher in TB subjects on ATT (2.33 ± 1.77) but decreased significantly in drug naive TB subjects (0.52±0.31) when compared with control subjects (1.09 ± 0.57) (p ¼ 0.000 respectively). Conclusion: We determined that as compared to control participants, BMI was considerably lower in both drug-naive PTB subjects and PTB subjects on ATT.