Journal of AdvancedMedical and Dental Sciences Research

Background: Gallstones are hardened deposits of the digestive fluid bile, that can form within the gallbladder. The present study was conducted to compare high and low-pressure carbon dioxide in patients undergoing laparoscopic cholecystectomy. Materials & Methods: 90 patients of cholelithiasis of both genders were randomly divided into 2 groups of 45 each. Group I experienced PaCO2 (high pressure) of 12-14 mmHg and group II (low- pressure), 7–10 mmHg. Results: There were 21 males and 14 females in group I and 24 males and 11 females in group II. SBP (mm Hg) at admission in group I and group II was 128.4 and 120.4, 1 hour after surgery was 124.2 and 116.8, 3 hours after surgery was 126.4 and 112.4 and 6 hours after surgery was 120.2 and 110.4 respectively. DBP (mm Hg) at admission in group I and group II was 76.4 and 72.0, at 1 hour after surgery was 72.4 and 70.3, at 3 hours after surgery was 70.2 and 68.5 and at 6 hours after surgery was 71.4 and 68.2 respectively. The mean heart rate at admission was 82.0 and 78.4, at 1 hour after surgery was 86.2 and 80.2, at 3 hours after surgery was 88.6 and 81.2 and at 6 hours after surgery was 80.4 and 84.2 in group I and group II respectively. The difference was significant (P< 0.05). There was significant difference in AST, ALT, ALP, BILLT and BILLD level pre- operatively and post- operatively in group I and II (P<0.05). Conclusion: Low pressure CO2 found to be superior as compared to high- pressure CO2 in laparoscopic cholecystectomy.