Journal of AdvancedMedical and Dental Sciences Research

Background: Cholelithiasis is one of the most common digestive tract diseases and constitutes an important health problem. The present study was conducted to evaluate efficacy of dexmedetomidine on hemodynamic stability in patients undergoing laproscopic cholecystectomy. Materials & Methods: 50 patients selected for laproscopic cholecystectomy of both genders were divided into 2 groups. Group I patients received dexmedetomidine 200 mcg (2ml) in 38 ml of 0.9% NS @ 0.2 µg/kg/hr infusion and group II patients received 0.9% saline was given at same rate. Parameters such as pulse rate, mean arterial pressure, oxygen saturation, EtCO2 and isoflurane requirement was recorded. Results: Group I had 13 males and 12 females and group II had 10 males and 15 females. The mean duration of surgery in group I was 50.2 hours and in group II was 48.9 hours, heart rate was 84.2 beats/min and in group II was 86.2 beats/min, SBP was 126.4 mm Hg in group I and 124.2 mm Hg in group II, DBP was 80.6 mm Hg in group I and 78.4 mm Hg in group II, MBP was 94.5 mm Hg in group I and 92.1 mm Hg in group II, SpO2% was 97.2% in group I and 98.4% in group II and EtCO2 in group I was 36.1 and in group II was 35.7. The difference was non- significant (P> 0.05). Conclusion: Dexmedetomidine infusion in the dose of 0.2µg/kg/h effectively attenuates haemodynamic stress response to pneumoperitoneum during laparoscopic surgery.