Journal of AdvancedMedical and Dental Sciences Research

Background: Tympanoplasty involves reconstruction of perforated tympanic membrane with or without ossiculoplasty. The present study was conducted to assess the intraoperative analgesic and sedative efficacy of two different loading doses of Dexmedetomidine for tympanoplasty. Materials & Methods: Sixty American Society of Anaesthesiologists (ASA) physical status grade I or II patients, age 16-65 years scheduled for tympanoplasty were enrolled in study. Patients were divided into 2 groups of 30. Group I patients received injection dexmedetomidine at a loading dose of 1.0 µg/kg and Group II received 0.5 µg/kg respectively over 10 min followed immediately by a continuous infusion of 0.4µg/ kg/h. Degree of sedation and pain intensity were assessed using Ramsay Sedation Score (RSS) and Visual Analogue Scale (VAS) respectively. Total rescue doses of Fentanyl and Midazolam as well as surgeon and patient satisfaction scores (Numerical Rating Scale NRS 0-10) were noted. All findings were recorded and compared in both groups and statistically determined. Results: SpO2 was 99.1 in group I and 99.4 in group II, mean SBP (mm Hg) was 120.4 and 126.2, mean DBP (mm Hg) was 78.4 and 72.0, mean respiratory rate (beats/min) was 14.5 and 13.9, surgeon satisfaction score was 8.7 and 6.7 and patient satisfaction score was 8.5 and 6.21 in group I and II respectively. The difference was significant (P< 0.05). Conclusion: Dexmedetomidine at loading dose of 1 µg/kg provides better sedation, analgesia, patient satisfaction and surgeon satisfaction as compared to loading dose of 0.5 µg/kg.