Journal of AdvancedMedical and Dental Sciences Research

Background: High blood pressure represents one of the potent cardiovascular risk (CV) factor and a leading cause of total and CV mortality. The present study was conducted to assess changes in physiological and biochemical parameters of arterial stiffness. Materials & Methods: 80 healthy subjects were subjected to brachial systolic blood pressure (bSBP), brachial diastolic blood pressure, central systolic blood pressure (cSBP), central diastolic blood pressure (cDBP), heart rate, augmentation index (AIx[%]) and baPWV were recorded after 10 min of rest. Mean arterial pressure (MAP), pulse pressure (PP) and PP ratio (PPR) estimation. Serum samples were analysed to estimate OPG level and lipid profile. Results: Out of 80 patients, males were 50 and females were 30. The mean age in males was 45.1 years in females was 47.3 years, height (cm) was 164.2 in males and 151.2 in females. Weight (Kg) was 65.4 and 62.1, BMI (Kg/m2) was 24.2 and 27.5, baPWV (cm/s) was 1216.5 and 1289.3, augmentation index (%) was 67.3 and 84.2, central SBP (mmHg) was 118.2 and 126.2, central DBP (mm Hg) was 79.1 and 82.5, central pulse pressure (mm Hg) was 39.2 and 45.8, central MAP (mm Hg) was 90.1 and 95.2, brachial SBP (mm Hg) was 128.2 and 134.6, brachial DBP (mm Hg) was 78.2 and 79.0, brachial pulse pressure (mm Hg) was 49.1 and 52.6, brachial MAP (mm Hg) was 96.2 and 96.0, pulse pressure ratio was 1.3 and 1.1 in males and females respectively. Cholesterol (mg/dl) was 190.2 and 191.3, triglyceride (mg/dl) was 142.3 and 142.7, LDLc (mg/dl) was 122.7 and 120.3, HDLc (mg/dl) was 40.6 and 41.2, VLDLc (mg/dl) was 28.1 and 29.1 and osteoprotegerin (pg/ml) was 46.2 and 45 in males and females respectively. The difference was significant (P<0.05). Conclusion: Serum OPG level and serum TG levels emerged as major factors, which influence baPWV values in both genders.