Journal of AdvancedMedical and Dental Sciences Research

Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate that allows one to obtain fibrin membranes enriched with platelets and growth factors after starting from an anticoagulant-free blood harvest without any artificial biochemical modification. The present study was conducted to evaluate role of PRF in treatment of infrabony defects. Materials & Methods: 40 patients of periodontal IBD of moderate–severe periodontitis of both genders were divided into 2 groups of 20 each. Group I were cases in which autologous PRF was used and in group II scaling and root planning was performed only. Parameters such as PPD, clinical attachment loss, defect depth and gain in clinical attachment was recorded. Results: Group I had 8 males and 12 females and group II had 9 males and 11 females. PPD (mm) at baseline, 3 months and 6 months in group I was 8, 6 and 2 and in group II was 8, 7 and 4 respectively. CAL (mm) at baseline, 3 months and 6 months in group I was 10, 6 and 3 and in group II was 10, 7 and 5 respectively. Gain in clinical attachment at baseline, 3 months and 6 months in group I was 0, 5 and 8 and in group II was 0, 3 and 5 respectively. Defect depth (mm) at baseline, 3 months and 6 months in group I was 10, 5 and 4 and in group II was 10, 7 and 6 respectively. The difference was significant (P< 0.05). Conclusion: PRF found to be effective in reduction in probing pocket depth, gain in clinical attachment level and significant radiographic defect bone fill in intrabony defects.