Journal of AdvancedMedical and Dental Sciences Research

Background: Periodontitis is a multi-factorial disease caused by the plaque micro-organisms. Although bacteria are primary etiological agents in periodontitis, host response to the infection sustaining is crucial to disease progression. The present study was conducted to assess procalcitonin level in saliva and serum of chronic periodontitis patients following nonsurgical periodontal therapy. Materials & Methods: 24 systemically healthy subjects age ranged 30-45 years of both genders with chronic generalized severe periodontitis were included. After saliva and serum collection, clinical parameters such as plaque index, gingival index, gingival bleeding index, probing pocket depth, and clinical attachment were recorded. ProCT was estimated using the enzyme-linked immunosorbent assay. Results: Out of 24 patients, males were 10 and females were 14. The mean PI at baseline was 2.32, at 1 month was 0.74 and at 3 months was 0.36. GI was 2.33, 0.81 and 0.28 at baseline, 1 month and 3 months respectively. GBI was 84.1, 24.6 and 12.1 at baseline, 1 month and 3 months respectively. PPD was 6.27, 4.45 and 3.74 at baseline, 1 month and 3 months respectively and CAL was 6.23, 4.75 and 4.28 at baseline, 1 month and 3 months respectively. The mean salivary procalcitonin level wat baseline was 0.21, at 1 month was 0.14 and at 3 months was 0.12. Serum procalcitonin level at baseline was 0.26, at 1 month was 0.14 and at 3 months was 0.13. The difference was significant (P< 0.05). Conclusion: There was gradual decrease in serum and salivary procalcitonin level following periodontal therapy.