Journal of AdvancedMedical and Dental Sciences Research

Antibiotics have become an integral part of the therapeutic armamentarium owing to the proven bacterial etiology of periodontal diseases. Many antibiotics can be used in conjunction with scaling and root planing, however, the emergence of bacterial resistance and side effects of the commonly used drugs warrants expansion of antibiotic spectrum and search of viable surrogates. This review aims to discuss Spiramycin a macrolide for its clinical efficacy in conjunction with non-surgical periodontal therapy in patients of advanced periodontitis. All literature available on PubMed, PubMed Central, MEDLINE, Google Scholar, and Google search engines was collected. The information extracted indicated that spiramycin is endowed with good antimicrobial activity with ability to achieve high concentrations in gingival crevicular fluid and saliva proving efficacious in terms of clinical parameters improvement in patients of advanced chronic periodontitis. It is a safe drug with potential usage in conditions where drugs like Penicillins or tetracyclines are contraindicated or show marked resistance.