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Volume 6 Issue 9 (September, 2018)

Original Articles

Assessment of asymptomatic bacteriuria and antibiotic sensitivity pattern among diabetic females- A pharmacological study
Dr. Sharad Chaddha, Dr. Shailendra Mishra

Background: The word Diabetes mellitus is derived from the Greek word Diabetes, which literally means siphon - to pass through. Asymptomatic bacteriuria (ABU) is the presence of bacteria in the properly collected urine of a patient that has no signs or symptoms of a urinary tract infection. Many studies have demonstrated the resistance of bacteria to various antibiotics results in conversion of ASB into symptomatic bacteriuria in UTI which leads to major complications among diabetic women. Hence; the present study was conducted for assessing asymptomatic bacteriuria and antibiotic sensitivity pattern among diabetic females. Materials & methods: A total of 100 diabetic females were analyzed. Subjects with presence of known type two DM with a history of minimum of past 5 years were enrolled. Mid-stream urine samples were collected and sent within one hour for processing. Microbiological profile was assessed. Antibiotic sensitivity pattern was also analyzed. Results: ABU was present in 21 percent of the patients. E. coli and K. pneumonia were found to be present in 52.38 percent and 23.80 percent of the patients with ABU. Coagulase negative staphylococci and Staphylococcus aureus were found to be present in 9.52 percent and 14.28 percent of the patients. E. coli was found to be sensitive mainly to Amikacin, Gentamicin, ciprofloxacin and Nalidixic acid while it was found to be resistant mainly to cephalotin and Vancomycin. Klebsiella pneumonia was found to be sensitive for Amikacin, Gentamicin, Ciprofloxacin and Cephalotin while it was found to be resistant mostly to Ceftriaxone, Nalidixic acid and Ampicillin. Conclusion: Based on the available antibiotic sensitivity patterns of the commonly isolated pathogens, appropriate empirical therapy for AUB can be instituted timely to reduce complications, such as pyelonephritis and other upper UTI

 
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