Journal of AdvancedMedical and Dental Sciences Research

Background: First trimester miscarriage, defined as pregnancy failure up to 13 completed weeks, affects nearly 25% of women in their reproductive age. The present study was conducted to assess efficacy of Mifepristone in induction of first-trimester miscarriage. Materials & Methods: 102 patients admitted to the department of Gynaecology & Obstetrics due to the first trimester miscarriage underwent repeatable doses of 800 mcg misoprostol vaginally. Type of miscarriage, gravidity, parity, time of drug administration were recorded. Results: BMI was 32.4 Kg/m2 in successful and 32.1 Kg/m2 in unsuccessful induction, time from previous delivery 3.61 years and 3.92 years respectively, History of miscarriages was 1 in 24 and 5 respectively, and >2 in 13 and 1 respectively, missed abortion was seen in 64 and 14 and blighted ovum in 18 and 6 respectively. Previous surgical interventions on uterus was seen in 11 and 5 in successful and in unsuccessful induction respectively. The difference was significant (P< 0.05). Conclusion: Pharmacological induction with Misoprostol is an effective and safe treatment method of first trimester abortion. Key words: Abortion, Induction, Misoprostol