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Volume 9 Issue 3 (March, 2021)

Original Articles

A Study of drug emerging metabolic syndrome in patients of schizophrenia receiving typical and atypical antipsychotics – A comparative study
Ramchandra Lamba, Neha Chodhary, Devendra Vijayvergia, Vinod

Background: The metabolic syndrome comprises of central obesity, elevated cholesterol and triglycerides, impaired glucose tolerance and increased blood pressure. The present study was conducted to estimate the % of metabolic syndrome in patients of schizophrenia taking antipsychotic medication (typical and atypical) at the initiation of therapy and 3 months after initiation. Materials & Methods: The sample was divided into two groups, each comprising of 50 patients (group A- patients on typical antipsychotic drugs and group B– patients on atypical antipsychotic drugs). A semi–structured, self–designed proforma which included socio demographic details and clinical profile of patients was recorded. Metabolic parameters were recorded before the onset of treatment and 3 months after the initiation of treatment. Results: Age of subjects was found between 18-60 years, with majority (40%) of them were from the age group of 31-40 years, whereas 35% were from age group of 18- 30 years, 25% from 41-60 years. Majority (70%) of the participants had past history of psychiatric illness, 30% participants had no history of any psychiatric illness. The prevalence of metabolic syndrome was 18 % in group A and 42% in group B, overall prevalence was 30%. Prevalence of metabolic syndrome was 18 % in group A and 42% in group B. In majority (73.33%) of patients waist circumference was increased, followed by decrease HDL cholesterol in 66.67%, increase TG in 63.33%, increase blood sugar in 50% and increase blood pressure was in 43.33%. Conclusion: Overall occurrence of metabolic syndrome was 30%. Occurrence of metabolic syndrome in male patients was 25% and in female patients was 35.42%. Key words: Metabolic syndrome, Psychiatric, Schrizophrenia.

 
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