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Volume 7 Issue 7 (July, 2019)

Original Articles

A comparative evaluation of glimepiride plus metformin versus glibenclamide plus metformin in type 2 diabetes mellitus patients
Roohi Sharma, Vinay Sambyal, Brij Mohan Gupta, Mohammad Saleem Sharoo, Zahid Gillani

Background: The present study was conducted to assess the efficacy of combination therapy in management of patients with type 2 diabetes mellitus. Materials & Methods: 140 patients of type 2 diabetes mellitus were divided into 2 groups of 70 patients each. Group I received combination of glimepiride plus metformin and group II received combination of glibenclamide plus metformin. Estimation of fasting plasma glucose and HbA1C before and 3 and 6 months after treatment was done. Results: The mean fasting blood glucose level in group I before treatment was 184.2 mg/dl and in group II was 174.6 mg/dl, after 3 months was 128.8 mg/dl in group I and 124.2 mg/dl in group II, at 6th month was 104.2 mg/dl and 112.7 mg/dl in group I and group II respectively. HbA1C level in group I was 8.1% and in group II was 8.3%, after 3 months was 7.3% and 7.2% in group I and group II respectively. At 6th month was 6.6% in group I and 6.0% in group II respectively. The difference was significant (P< 0.05). Conclusion: Glimepiride plus metformin and glibenclamide plus metformin found to be equally effective in patients with type 2 diabetes mellitus, thus selection of patients should be done based on patient response. Key words: Diabetes mellitus, Glimepiride, Metformin.

 
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