Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was conducted to assess histomorphological features of pancreas and liver in chronic alcoholics. Materials & Methods: 114 liver and pancrease autopsies of both genders were was differentiated from ante-mortem changes histologically. H and E staining was done in all the sections, reticulin, Mason's trichrome and Elastic Van Giesen stainings were also carried out. Results: Gross features were enlarge in 73, shrunken in 30 and normal in 11 cases. Micronodules were seen in 64, macronodules in 36 and non- cirrhotic with normal liver in 14. Consistency was firm in 71, soft in 15, normal in 11 and necrosis was 28. The difference was significant (P< 0.05). Distribution of pancreatic fibrosis found to be Focal in 1 and 0, diffuse in 2 and 1, perilobular in 11 and 2, intralobular in 4 and 0, periductal in 2 and 1, calcifying pancreatitis in 3 and 0, ductal epithelial mucinous metaplasia in 2 and 1 in cirrhotic and non- cirrhotic in pathologic pancreatic features. Conclusion: Parenchymal fibrosis was more frequently seen in alcoholic cirrhosis cases than that in non-cirrhotic alcoholic liver disease. Key words: Alcoholic liver disease, Parenchymal fibrosis, Pancrease