Journal of AdvancedMedical and Dental Sciences Research

Background: Oral leukoplakia is a premalignant lesion described as a predominant white lesion of the oral mucosa which cannot be defined as any other known lesion”. Aim: The study was to compare topical bleomycin and topical steroid in the treatment of oral leukoplakia. Material and methods: The present study was conducted to compare topical bleomycin and topical steroid in the treatment of oral leukoplakia. Forty patients were identified with a diagnosis of leukoplakia and were enrolled in the study and divided into two groups. Group I was treated with topical bleomycin and Group II was treated with topical steroid. Results: In the present study group I patients were treated with bleomycin and Group II were treated with topical steroid. In group I speckled leukoplakia was present in 6 patients, homogenous leukoplakia in 12 patients, 2 patients had leukoplakia within no limits. In group II speckled leukoplakia was present in 5 patients, homogenous leukoplakia in 11 patients, 4 patients had leukoplakia within no limits. In group I mild dysplasia was present in 9 patients, moderate dysplasia was present in 4 patients, 7 patients had severe dysplasia. In group II mild dysplasia was present in 8 patients, moderate dysplasia was present in 3 patients, 9 patients had severe dysplasia. Patients after immediate treatment in Group I shows Homogenous leukoplakia in 13 patients, minimum leukplakia in 5 patients, 2 patients had leukoplakia within limits. In Group II Homogenous leukoplakia was present in 11 patients, minimum leukplakia in 4 patients, 5patients had leukoplakia within limits. In group I normal epithelium was present in 4 patients and benign hyperkeratosis in 16 patients. In group II normal epithelium was present in 2 patients and benign hyperkeratosis in 18 patients. Conclusion: Our study concluded that topical bleomycin was better than topical steroid in treating oral leukoplakia. Key words: oral leukoplakia, steroid, bleomycin, mild dysplasia.