Journal of AdvancedMedical and Dental Sciences Research

Introduction: Osteoarthritis (OA) is a chronic progressive disease of the weight-bearing joints characterized by degeneration of articular cartilage, subchondral sclerosis, osteophyte, and cyst formation. The present study compared Etodolac and diclofenac sodium in patients of OA of knee joint. Materials & Methods: The present study was conducted on 68 patients of osteoarthritits of both genders. Patients were divided into 2 groups of 34 each. Group I patients were given tablet etodolac 400 mg bid and in group II patients, tablet diclofenac sodium 50 mg tid was given. Patients were reassessed at 3, 6, and 12 weeks after starting treatment according to the Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis index (WOMAC). Results: Group I patients revealed very good response in 2, good in 30 patients and fair in 2 patients, group II patients revealed very good response in 1, good in 28 patients and fair in 5 patients. The difference was significant (P< 0.05). The mean Western Ontario and McMaster Universities Osteoarthritis score in group I was 45.2, 34.2, 20.6 and 14.6 at 0 week, 3 weeks, 6 weeks and 12 weeks. In group II was 50.2, 40.1, 25.8 and 18.5 at 0 week, 3 weeks, 6 weeks and 12 weeks. The difference was significant (P< 0.05). The mean VAS score in group I was 70.2, 50.8, 30.2 and 14.6 at 0 week, 3 weeks, 6 weeks and 12 weeks. In group II was 70.4, 62.4, 35.1 and 20.4 at 0 week, 3 weeks, 6 weeks and 12 weeks. The difference was significant (P< 0.05). Conclusion: Authors found that etodolac found to be better as compared to diclofenac sodium in patients of knee osteoarthritis. Key words: osteoarthritis, etodolac, Diclofenac sodium