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Volume 7 Issue 8 (August, 2019)

Original Articles

Evaluation of intrathecal clonidine and magnesium sulphate used as an adjuvant with bupivacaine in lower abdominal surgery
Parag Agarwal, Bhrigu Nath Singh

Background: Various drugs used as adjuvants to spinal anaesthesia are known to provide intra- and post-operative analgesia. The present study was designed to evaluate and compare the analgesic efficancy of clonidine and magnesium sulphate when used as an adjuvant to intrathecal bupivacaine. Material and methods: The present prospective, placebo-controlled study was done in 40 patients of age 20-50 years with the American Society of Anesthesiologists' (ASA) physical status grade I or II, height between 140 to185cm, weight between 40 to 80 kg, posted for elective lower abdominal surgery under spinal anaesthesia over the period of 6 months was done. Patients in Group A  received 3 mL of 0.5% hyperbaric bupivacaine with 1 mL of normal saline, those in Group B received 3 mL of 0.5% hyperbaric bupivacaine with 1 mL (30μg) of clonidine (1:5 dilution) and patients in Group C received 3 mL of 0.5% hyperbaric bupivacaine with 1 mL (50mg) magnesium sulphate (1:10 dilution).Statistical analysis was done with Statistical Package for the Social Science version 21.0.0 (SPSS Inc., Chicago, Illinois, USA) and p value <0.05 was taken to be statistically significant. Results: Results of the study shows that mean age of Group C was more than Group A and Group B. Duration of surgery for Group C was more than group A and Group B. Onset of motor block for Group C (8.14±4.6) was more than Group A and Group B. Duration of motor block for Group C (136.88±39.5) was more than Group A and Group B. Conclusion: Intrathecal clonidine long-lasting post-operative analgesia along with earlier onset and prolonged duration of sensory and motor blockade compared to both magnesium and control. Intrathecal magnesium also increased the analgesic duration compared to control but it was associated with delayed onset of both sensory and motor blockade compared to both clonidine and control.
Key words: Bupivacaine, magnesium sulphate, clonidine.

Received: 13 May, 2019                            Revised:  10 June 2019                             Accepted: 12 June 2019

Corresponding author: Dr. Bhrigu Nath Singh, Associate Professor, Department of Anesthesia, Autonomous State Medical College, Ayodhya

This article may be cited as: Agarwal P , Singh BN. Evaluation of intrathecal clonidine and magnesium sulphate used as an adjuvant with bupivacaine in lower abdominal surgery. J Adv Med Dent Scie Res 2019;7(8): 198-200.

 
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