Journal of AdvancedMedical and Dental Sciences Research

Background: Hypertensive disorders of pregnancy affect one of every ten pregnant women, and are one of the leading causes of maternal and perinatal mortality and morbidity. The present study was conducted to compare oral labetalol and oral nifedipine in hypertensive disorders of pregnancy. Materials & Methods: The present study was conducted on 120 pregnant women. Preterm or term pregnant women with severe preeclampsia/ eclampsia and BP ≥160/100 mm Hg were included in the study. Patients were divided into 2 groups of 60 each. Group I patients were given oral labetalol and group II were given oral 10 mg Nifedipine. Results: Primi was seen in 36 in group I and 34 in group II, G2 12 in group I and 10 in group II, G3 8 in group I and 10 in group II and G4 4 in group  and 6 in group II. The difference was non- significant (P> 0.05). In group I, SBP was 172.4 mm Hg in group I and 164.2 mm Hg in group II, DBP was 112.6 mm Hg in group I and 110.8 mm Hg in group II. The difference was significant (P< 0.05). Neonatal outcome was better in nifedipine but difference was non significant. Conclusion: Authors found oral Nifedipine better in terms of lowering blood pressure in pregnant ladies. However difference was non- significant.
Key words: Blood pressure, Nifedipine, labetalol.

Received: 20 March, 2019                                         Revised:  27 April, 2019                            Accepted: 29 April, 2019

Corresponding Author: Dr. Mridula Sharma, Department of Obstetrics & Gynaecology, Rajshree Medical Research Institute, Bareilly, Uttar Pradesh, India

This article may be cited as: Agarwal K, Sharma M. A comparative study to evaluate the efficacy of Oral Labetalol and Oral Nifedipine in hypertensive disorders of pregnancy. J Adv Med Dent Scie Res 2019;7(7): 147-150.