Journal of AdvancedMedical and Dental Sciences Research

Background: OSMF is a potentially malignant disease of the oral cavity. The present study was conducted to compare the effect of Placental extracts and Hyaluronidase in cases of OSMF. Materials & Methods: The present study was conducted on 24 patients of OSMF. All were divided into 2 groups. Group I were prescribed 2ml of placental extract and group II patients were put on 1500 IU of Hyaluronidase. In all patients, mouth opening was measured before and after treatment. Pain was measured on VAS before and after treatment. Results: In group I, the mouth opening was 24.2 mm and after treatment 32.4 mm. In group II, it was 26.3 mm before treatment and 33.8 mm after treatment. The difference was significant (P< 0.05). The mean burning sensation on VAS score was 7.2 and 1.4 before and after treatment in group I. It was 6.8 and 1.6 before and after treatment in group II. The difference was significant (P< 0.05). Conclusion: Both hyaluronidase and Placental extracts resulted in significant improvement in mouth opening and reduction in burning sensation. Key words: OSMF, Hyaluronidase, Placental extracts