Background: Inducing agents aredrugs when given intravenously cause rapid loss of consciousness. Etomidate and propofol are ultra-short-acting tranquillizing agents that provide these characteristics.Few of the side effects that occur with Propofol are blood pressure drop, ventilation depression in a dose dependent manner and pain during injection.The present study was done to assess the hemodynamic changes and complication occurring with Propofol and etomidate during general anesthesia. Materials & Methods: The present study enrolled 60 subjects that belonged to ASA grade I and II. The subjects undergoing surgical treatment under general anesthesia were enrolled in the study. Group I subject received 1% Propofol injection and Group II subjects received 0.3mg/kg of etomidate. Pre-medication was given with 0.25 mg alprazolam tablets and 150 mg ranitidine tablets. Patientís myoclonic activity and pain during injection were recorded at the time of induction. All the data was arranged in a tabulated form and analyzed using SPSS software. Student t test was used for analysis and probability value of less than 0.05 was considered as significant. Results: Table I shows that out of 60 patients, 30 were in group I and 30 in group II. The male to female ratio in Group I was 2:1 and in Group II was 1:1. In group I, a significant decrease in MAP from baseline at induction with Propofol was seen compared to etomidate. The mean arterial pressure of both the groups was comparable (p> 0.05). In group II, number of patients with grade I, grade II and grade III pain were 25 (83.3%), 3 (10%) and 2(6.7%) respectively. The difference was statistical significant (p- 0.02). Conclusion: From the present study we can conclude that etomidate is a improved option amongst patients especially those who are prone to hemodynamic changes
Key words: Induction agents, Etomidate, mean arterial pressure, propofol.