Background:Infection of the eye leads to conjunctivitis, keratitis, endophthalmitis, dacryocystitis, blephritis, infections of eye lid, microbial scleritis, canaliculitis, preseptal cellulitis, orbital cellulitis, endophthalmitis and panophthalmitis etc., which are responsible for increased incidence of morbidity and blindness worldwide.Under the light of above mentioned data, we planned the present study to assess the efficacy of two different antibiotics in treating patients with ocular infection. Materials & methods: The present study included assessment of efficacy of different antibiotic therapy in treating patients with ocular infection. A total of 50 patients with external ocular infections were included in the present study. All the patients were broadly divided into two study groups as follows: Group A: included patients who were treated with 0.3% ofloxacin solution for seven days,Group B: included patients who were treated with 0.5% chloramphenicol solution for seven days. Clinical and microbiological characterization of all the patients was done by obtaining swab from the margin of the eyelid. Clinical and microbiological cure in all the patients was assessed. All the data were summarized in Microsoft excel sheet and were analyzed by SPSS software. Results: Clinical improvement occurred in 100 percent of cases in group A while it occurred in 96 percent of the cases respectively. Microbiological improvement was seen in 22 and 23 cases of group A and group B respectively. Overall, improvement rate among subjects of group A and group B was similar (88 percent). Conclusion: Both the antibiotic regimes can be used with equal efficacy in treating patients with ocular infections. However; further studies are recommended.
Key words: Antibiotics, Infection, Ocular