Background: Cirrhosis is frequently indolent, asymptomatic and unsuspected until complications of liver disease present.The Child-Pugh Class A patients usually show a good median survival term without OLT unless other events. The aim of the present study is to assess association of lipid profile with severity of the disease in liver cirrhosis patients. Materials and methods: The present prospective study was conducted in the medicine department of Government medical college, Patiala. Classification of all the patient’s were done on the basis of child pugh’s criteria. A complete demographic detail and medical history of all the subjects were noted. Student t test was used for analysis. P value of less than 0.05 was regarded as significant. Results: The mean age in cirrhotic group was 50.5 +/- 6.36 years and the mean age in control group was 50.26+/- 6.58 years. Mean LDL cholesterol levels were 106+20.68 in Child group A, 80.74+5.47 in Child group B and 72.14+5.40 in Child group C. Mean HDL cholesterol levels were 36.28+2.72 in Child group C, 40.06+2.54 in Child group Band 41.31+3.32 in Child group A. Conclusion: The study has shown that total cholesterol, VLDL, HDL, Triglycerides and LDL content decreases as the severity of disease/cirrhosis increases and it was statistically significant as the p value was <.00001.
Key words: Cholesterol, Cirrhosis, Triglycerides.