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Volume 6 Issue 11 (November, 2018)

Case Reports

Langerhans Cell Histiocytosis - A Review and Case Report
Parul Chhabra, Pujit Chhabra, Saanvi Sihag, Mohit Kumar, Sushila Kumari

Langerhans cell histocytosis (LCH), formerly known as histiocytosis X is a selectively rare disease with an incidence of 2-5 cases per million. It refers to group of conditions characterized by uncontrolled stimulation and proliferation of normal antigen-processing bone marrow derived cell- langerhans cells. Langerhans cells histocytosis mainly affects the skull, vertebrae, ribs, maxilla and mandible in children and the long bones of adults. Symptoms range from none to pain, swelling and tenderness over the site of lesion, gingival enlargement, oral ulcers, and mobility of teeth. This disease presents oral manifestations which can be expression of the systemic condition, hence diagnosing such lesion becomes difficult for oral physicians, and LCH is confirmed by histological, immune histochemical staining. These lesions are commonly seen in childhood; we report a case of 15 years old male child, who presented with swelling of gums, mobility of almost all teeth since 6 months. On the basis of histological and immune histochemical features (tumor cells are positive for CD 1a and S100 protein); a diagnosis of langerhans cell histocytosis was made.
Key words: Histiocytosis X, langerhans cell histocytosis,

Received: 12 September  2018                                 Revised: 22 October 2018                              Accepted: 25 October 2018
Corresponding author: Dr. Parul Chhabra,   Chhabra Dental Clinic, Opp. Civil Hospital Narwana, Distt – Jind, Haryana, Pin Code- 126116

This article may be cited as: Chhabra P, Chhabra P, Sihag S, Kumar M, Kumari S. Langerhans Cell Histiocytosis – A Review and Case Report. J Adv Med Dent Scie Res 2018;6(11):71-73.

 
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