Journal of AdvancedMedical and Dental Sciences Research

Background: Hypertension is an increasingly prevalent chronic condition that is associated with serious morbidity and mortality. The present study was conducted to compare metoprolol and nebivolol in management of hypertension. Materials & Methods: The present study was conducted on 64 patients (males- 32, females- 32) age ranged between 18-60 years. They were divided into 2 groups of 32 patients each. Group I (16) received 10 mg nebivolol and in group II received 25 mg metoprolol. All were recalled to record blood pressure on day 1, day 25 and day 45.  Results: Mean age ±S.D (years) in group I was 45± 4.5 and in group II was 43± 4.8. BMI (Mean± S.D) (Kg/m2) in group I was 23.1± 1.2 and in group II was 24.2± 1.6. The difference was non- significant (P> 0.05). In group I, the mean SBP ±SD was 162.4± 4.8, on 25th day was 150.2± 3.4 and on 45th day was 141.6 ± 2.5. In group II, the mean SBP ±SD was 164.1± 4.2, on 25th day was 152.4± 3.2 and on 45th day was 140.2 ± 2.7. The difference was significant within the group (P< 0.05) whereas on comparison between the both groups, the difference was non- significant (P> 0.05). In group I, there was no change in quality of life in 45%, minor change in 35% and moderate change in 20% whereas in group II, there was no change in 47%, minor change in 40% and moderate change in 13%. The difference was non- significant (P> 0.05). Conclusion: Both nebivolol and metoprolol found to be equally effective in patients with hypertension. Lifestyle and habits play an important role.
Key words: Hypertension, Metoprolol, Nebivolol
Corresponding author: Dr . Vinita Bharti, Assistant Professor, Department of Pharmacology, Integral Institute of Medical Science & Research Lucknow, U.P., India            
This article may be cited as:  Bharti V. A Comparative Assessment of Metoprolol and Nebivolol in Management of Hypertension- A Clinical Study. J Adv Med Dent Scie Res 2015;3(1):222-224.