Background: Spinal anesthesia is successful in alleviating postoperative pain which stretches out for long in postoperative period. Various methods have been attempted with a specific goal to make postoperative period free from agony. In this study anaesthetic properties of 0.5% hyperbaric bupivacaine with 0.4 ml saline and 0.5%hyperbaric bupivacaine with 2 mg of midazolam given intrathecally were compared. Materials and Methods: Patients of either sex (male = 44, female = 16), aged between 25-60 years, were randomly allotted to two groups (30 each). Group 1 patients were given 0.5% hyperbaric bupivacaine with saline intrathecally, and Group 2 patients were administered 0.5% hyperbaric bupivacaine with preservative free midazolam 2 mg intrathecally. Peak sensory level, motor blockade, duration of analgesia, pain score (on VisualAnalogue Scale), heart rate and blood pressure were monitored.Results: The duration of analgesia was higher in Group 2 (321 ± 25.5 minutes) versus Group 1 (157 ± 17.4minutes), and the pain score was less in Group 2 when compared with Group 1. The time of onset of sensory and motor block was longer in group 1. Hemodynamic changes did not vary in patient of either group. The side effects were negligible in both the groups. Conclusion: Intrathecal administration midazolam in with hyperbaric bupivacaine 0.5% delivers better quality of analgesia, longer span of absence of pain, with mellow sedation and negligible adverse symptoms.
Key Words: Hyperbaric bupivacaine, intrathecal midazolam, spinal anesthesia, postoperative analgesia.
Corresponding author: Dr. Shipra Singh, H.No. 202/A, Insaf Nagar, Indranagar, Lucknow-226016
This article may be cited as: Vaid VN, Singh S, Mishra P, Rao KG. Effect of Intrathecal Hyperbaric Bupivacaine with Midazolam and Hyperbaric Bupivacaine alone in Lower Limb Orthopaedic Surgery. J Adv Med Dent Scie Res 2017;5(9):60-63.