Journal of AdvancedMedical and Dental Sciences Research

Background: Laparoscopic cholecystectomy (LC)is one of the commonly employed surgical procedures these days. It is indicated for the treatment of cholecystitis (acute/chronic), symptomatic cholelithiasis, biliary dyskinesia, acalculous cholecystitis, gallstone pancreatitis, and gallbladder masses/polyps. Studies from the past literature have shown significant alterations in the liver functional tests (LFT) in patients undergoing LC. Hence; we planned the present study to evaluate effect of carbon dioxide pneumoperitoneum (CDP) on liver functions following LC. We also aim to analyse the overall incidence of these alterations in same patients. Materials & methods: The present study included evaluation of alterations in LFT in patient undergoing LC. A total of 200 subjects were included in the present study. All the patients underwent LC for the treatment of gall stones. In all the patients, pre-operative assessment of LFT was done which included evaluation of SGOT (aspartate aminotransferase), SGPT (alanine aminotransferase), total bilirubin (TB), direct bilirubin (DB) and alkaline phosphatase (ALP). All the values were evaluated post-operatively also after twenty four time. LC was carried out in all these patients using standard procedure as described previously in the literature. Comparative evaluation of all the parameters was done in relation to LFTs at pre-operative and post-operative time. All the results were analysed by SPSS software. Results: In the present study, we included a total of 200 subjects, out of which 154 were females and 46 were males. Significant results were obtained while comparing the mean SGOT, SGPT, TB and DB levels in patients undergoing LC at pre-operative and post-operative time. However, while comparing the mean AP values, non- significant results were obtained. The overall increase in the mean SGOT, SGPT, TB and DB values was seen in 95 %, 93 %, 73 % and 70% subjects respectively. Conclusion: Alteration in hepatic profile does occur in patients undergoing LC. Proper assessment of safety measures of LC procedure should be taken in patients with hepatic disorders.
Key words: Laparoscopic cholecystectomy, Liver functional tests