Journal of AdvancedMedical and Dental Sciences Research

Background: Gallstones are the most common & costly digestive disease, it is estimated that more than one million new cases emerge annually worldwide. Since there is little known about the role of Glycopyrrolate in laparoscopic surgeries; this study focuses on prophylactic role of Glycopyrrolate Bromide in prevention of bradycardia during laparoscopic cholecystectomy. Materials and methods: Prospective, randomized, double blind comparative study was designed to include 50 patients. Control group (25 patients) was given 1 ml of normal saline and Glycopyrrolate group 1ml = 0.2  mg of Glycopyrrolate during induction of anaesthesia. Data of Heart rate, Systolic and Diastolic Blood Pressure, Mean Arterial Pressure were taken in following manner: baseline (B); 1min after drug / normal Saline (Agent 1); 1 & 5 mins after intubation respectively (I 1 & 5); 1,3,5,15 & 30 mins after Pneumoperitoneum respectively (P ;1,3,5,15 & 30); Before Extubation (E b); After Extubation (E a). Results: There was a significant difference in heart rate specially after one, three and five minutes of pneumoperitoneum between group p and g (p < 0.05). Diastolic and systolic blood pressure, in both groups also did not changed significantly following administration of agent and event after laryngoscopy and intubation. In both groups heart rate, systolic blood pressure & diastolic blood pressure increased after extubation, but were within acceptable range; comparison between the two groups was not significant. Conclusion: Preoperative glycopyrrolate as premedication has a cardioprotective role and should be considered during laparoscopic cholecystectomy to prevent these disastrous consequences which has potential to take life of otherwise healthy individual.
Keywords: Blood pressure, glycopyrrolate, heart rate, laparoscopic Cholecystectomy.