Journal of AdvancedMedical and Dental Sciences Research

Background: Acid phosphatases are a family of enzymes that are widespread in nature and can be found in many animal and plant species. The greatest concentration of acid phosphatase (ACP) activity occurs in liver, spleen, milk, erythrocytes, platelets, bone marrow, and the prostate gland. The present study was conducted to evaluate the levels of acid phosphatase in patients with malaria. Materials & Methods: In present study subjects were divided into 3 groups.  Group I- included 20 patients suffering from (7 P. falciparum malaria), 7 with P. vivax malaria and 6 with mixed malaria. Group II- included 20 non malarial fever patients. Group III- included 20 healthy subjects. For detection of malarial parasite, a finger prick sample was taken. The hemoglobin (Hb) content of erythrocytes was determined by the Cyanmethaemoglobin method. Results: Out of 60 examined subjects, 30 were males and 30 were females. The difference was statistical non significant (P-1). Subjects were divided into 3 groups. Group I included 20 malarial patients, group II (non malarial fever) had 20 patients and group III had normal healthy subjects. The mean age of 7 patients suffering from P. malaria was 30.24 years, P. vivax 34.65 years, mixed malaria 35.11 years. The mean age of patients in group II was 36.27 years and in group III was 32.29 years. The difference was statistical non significant (p > 0.05). ACP level in P. falciparum is 7.21, in P.vivax is 6.78, in mixed malarial is 7.82, in group II patients 3.46 and in group III 2.12. The difference was significant (P < 0.05). Hemoglobin (Hb) level in patients suffering from P. falciparum was 10.11 gm%, in P. vivax was 10.69 gm%, in mixed malarial was 10.01 gm%, in group II patients was 11.86 gm% and in group III subjects 13.42 gm%. The difference in Hb level was significant (P < 0.05). Conclusion: There is increase in acid phospahatase level in patient with malaria. This is used as a diagnostic marker. The level of Hb was decreased in all malaria patients which indicates that malarial parasite uses host erythrocytes Hb as major nutrient source.
Key words: Malaria, P. falciparum, P. vivax

Corresponding author: Dr. Anjuli Kapoor, Associate Professor, Department of Biochemistry, Rajshree Medical College, Bareily, U.P., India.

This article may be cited as: Kapoor A, Kaur J. Usefulness of acid phosphatase level in malarial patients- A clinical study. J Adv Med Dent Scie Res 2017;5(1):123-126.